Reactome | Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

Stable Identifier

R-HSA-6802925

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

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RAF dimerization and phosphorylation downstream of oncogenic RAS and RAF mutations is associated with increased MAP2K and MAPK phosphorylation (Wan et al, 2004; Garnett et al, 2005; reviewed in Holderfield et al, 2014). Although the interactions between oncogenic RAS or RAFs and downstream effectors hasn't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
24957944	Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond McCormick, F, Deuker, MM, McMahon, M, Holderfield, M	Nat. Rev. Cancer	2014
16364920	Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization Garnett, MJ, Barford, D, Paterson, H, Rana, S, Marais, R	Mol. Cell	2005
15035987	Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Niculescu-Duvaz, D, Lee, S, Marais, R, Marshall, CJ, Barford, D, Jones, CM, Good, VM, Springer, CJ, Wan, PT, Garnett, MJ, Roe, SM	Cell	2004
21779496	Raf family kinases: old dogs have learned new tricks Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A	Genes Cancer	2011