Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

Stable Identifier
R-HSA-6802925
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
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RAF dimerization and phosphorylation downstream of oncogenic RAS and RAF mutations is associated with increased MAP2K and MAPK phosphorylation (Wan et al, 2004; Garnett et al, 2005; reviewed in Holderfield et al, 2014). Although the interactions between oncogenic RAS or RAFs and downstream effectors hasn't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
16364920 Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

Garnett, MJ, Rana, S, Paterson, H, Barford, D, Marais, R

Mol. Cell 2005
24957944 Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

Holderfield, M, Deuker, MM, McCormick, F, McMahon, M

Nat. Rev. Cancer 2014
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R

Cell 2004
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Normal reaction
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2015-05-18)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-02)