High kinase activity BRAF complexes phosphorylate MAP2Ks

Stable Identifier
R-HSA-6802911
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Highly active BRAF mutants such as V600E are constitutively active and phosphorylate MAP2Ks in a RAS- and dimer interface-independent manner (Davies et al, 2002; Wan et al, 2004; Garnett et al, 2005; Roring et al, 2012; Poulikakos et al, 2010; reviewed in Lavoie and Therrien, 2015).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer