Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane]
Stable Identifier
R-HSA-6802621
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAF is phosphorylated downstream of oncogenic RAS (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-RAF/BRAF homo/heterodimer [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (Homo sapiens)
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1:YWHAB [plasma membrane] (Homo sapiens)
Participants
components
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(Homo sapiens)
YWHAB [cytosol]
(Homo sapiens)
Participates
as a component of
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
p-S338,T491,S494,S621 RAF1:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S338:Y341,T491,S494 RAF1:YWHAB:p-S445,T599,S602,S729 BRAF:YWHAB dimer [plasma membrane] (Homo sapiens)
as a member of
phosphorylated RAFs:YWHAB [plasma membrane] (Homo sapiens)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text