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p-PAPD7-RAF1 fusion [cytosol]
Stable Identifier
R-HSA-6802541
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by BRAF and RAF fusions (Homo sapiens)
BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25204415
The landscape of kinase fusions in cancer
Stransky, N
,
Cerami, E
,
Schalm, S
,
Kim, JL
,
Lengauer, C
Nat Commun
2014
External Reference Information
External Reference
UniProt:Q5XG87 TENT4A
Gene Names
TENT4A, PAPD7, POLS, TRF4
Chain
chain:1-772
Reference Genes
BioGPS Gene:11044 TENT4A
CTD Gene:11044 TENT4A
dbSNP Gene:11044 TENT4A
ENSEMBL:ENSG00000112941 PAPD7
ENSEMBL_homo_sapiens_GENE:ENSG00000112941 TENT4A
HGNC:16705 TENT4A
KEGG Gene (Homo sapiens):11044 TENT4A
Monarch:11044 TENT4A
NCBI Gene:11044 TENT4A
OMIM:605198 TENT4A
UCSC:Q5XG87 TENT4A
Reference Transcript
RefSeq:NM_001171805.1 TENT4A
RefSeq:NM_001171806.1 TENT4A
RefSeq:NM_006999.4 TENT4A
Other Identifiers
11044
16982959
2800532
2800533
2800534
2800535
2800537
2800538
2800539
2800542
2800544
2800547
2800550
2800553
2800554
2800556
45487
46742
8104378
A0A0X1KG68
CCDS3871
D6RJD0
ENSG00000112941
ENSP00000488642
ENST00000631941
EntrezGene:11044
GO:0000166
GO:0000278
GO:0003674
GO:0004652
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005654
GO:0005730
GO:0005737
GO:0005794
GO:0006259
GO:0006302
GO:0006378
GO:0006397
GO:0006399
GO:0006950
GO:0007049
GO:0007059
GO:0007062
GO:0007076
GO:0008150
GO:0009056
GO:0016740
GO:0016779
GO:0031499
GO:0031965
GO:0032991
GO:0034641
GO:0034655
GO:0042493
GO:0043167
GO:0043221
GO:0043226
GO:0043630
GO:0046872
GO:0051276
GO:0071035
GO:0071036
GO:0071037
GO:0071038
GO:0071042
GO:0071044
GO:0071050
GO:0071051
GO:0140014
HGNC:16705
IPR002058
IPR002934
MIM:605198
NM_001171805
NM_006999
NP_001165276
NP_008930
PF01909
PF03828
TENT4A
TENT4A-207
uc284pwu.1
UPI0000071E30
XM_011513945
XM_017008988
XM_017008989
XP_011512247
XP_016864477
XP_016864478
XP_024310111
Participant Of
hasComponent
p-PAPD7-RAF1 fusion dimer [cytosol]
Other forms of this molecule
PAPD7-RAF1 fusion [cytosol]
Modified Residues
Name
Insertion of residues 331 to 648 at 654 from UniProt:P04049 RAF1
Coordinate
654
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 338
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-threonine at 491
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name
Identifier
Synonyms
cancer
162
malignant tumor, malignant neoplasm, primary cancer
prostate adenocarcinoma
2526
adenocarcinoma of prostate (disorder), prostate adenocarcinoma
Cross References
RefSeq
NP_001165276.1
,
NP_001165277.1
,
NP_008930.1
OpenTargets
ENSG00000112941
GeneCards
Q5XG87
PRO
Q5XG87
BRENDA (Homo sapiens)
2.7.7.19
HMDB Protein
HMDBP11873
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