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PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol]
Stable Identifier
R-HSA-6802541
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25204415
The landscape of kinase fusions in cancer
Kim, JL
,
Schalm, S
,
Stransky, N
,
Lengauer, C
,
Cerami, E
Nat Commun
2014
External Reference Information
External Reference
UniProt:Q5XG87 TENT4A
Gene Names
TENT4A, PAPD7, POLS, TRF4
Chain
chain:1-792
Reference Genes
BioGPS Gene:11044 TENT4A
COSMIC (genes):TENT4A TENT4A
CTD Gene:11044 TENT4A
dbSNP Gene:11044 TENT4A
ENSEMBL:ENSG00000112941 PAPD7
HGNC:16705 TENT4A
KEGG:hsa:11044 TENT4A
Monarch:11044 TENT4A
NCBI Gene:11044 TENT4A
OMIM:605198 TENT4A
UCSC:Q5XG87 TENT4A
Reference Transcript
RefSeq:XM_005248234.3 TENT4A
RefSeq:NM_001171805.1 TENT4A
RefSeq:NM_006999.4 TENT4A
RefSeq:NM_001171806.1 TENT4A
Other Identifiers
11044
11716283_at
11747912_a_at
11748383_a_at
16982959
202466_PM_at
202466_at
2800512
2800513
2800514
2800515
2800516
2800532
2800533
2800534
2800535
2800537
2800538
2800539
2800542
2800543
2800544
2800545
2800546
2800547
2800548
2800549
2800550
2800551
2800552
2800553
2800554
2800556
2800557
2800558
33380_at
44463_at
8104378
A_14_P128196
A_23_P18824
GE61899
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005794
GO:0006281
GO:0006302
GO:0006397
GO:0007062
GO:0007076
GO:0009410
GO:0016071
GO:0016740
GO:0016779
GO:0031123
GO:0031499
GO:0031965
GO:0043221
GO:0043226
GO:0043634
GO:0046872
GO:0060212
GO:0070568
GO:0071076
GO:1905870
GO:1990817
HMNXSV003005238
HMNXSV003006156
ILMN_1756793
PH_hs_0022109
TC05000045.hg
g6631114_3p_at
Participates
as a component of
p-PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
Other forms of this molecule
PAPD7(1-653)-RAF1(331-648) fusion [cytosol]
Modified Residues
Name
Insertion of residues 331 to 648 at 654 from UniProt:P04049 RAF1
Coordinate
654
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 338
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-threonine at 491
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name
Identifier
Synonyms
prostate adenocarcinoma
DOID:2526
adenocarcinoma of prostate (disorder), prostate adenocarcinoma
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_008930.1
,
XP_005248291.1
,
NP_001165276.1
,
NP_001165277.1
ENSEMBL
ENST00000230859
,
ENSP00000230859
OpenTargets
ENSG00000112941
HPA
ENSG00000112941-TENT4A
PRO
Q5XG87
Pharos - Targets
Q5XG87
GlyGen
Q5XG87
HMDB Protein
HMDBP11873
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75581 LRP6
8
LRP6 [plasma membrane]
(R-HSA-206252)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
LRP6N [extracellular region]
(R-HSA-5334021)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
0.589
2
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