Reactome | TP53 binds the PLK3 gene

TP53 binds the PLK3 gene

Stable Identifier

R-HSA-6802165

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 binds the PLK3 gene (Homo sapiens)

General

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TP53 (p53) binds the p53 response element in the promoter of the PLK3 (Polo-like kinase 3) gene (Jen and Cheung 2005).

Literature References

PubMed ID	Title	Journal	Year
16140933	Identification of novel p53 target genes in ionizing radiation response Jen, KY, Cheung, VG	Cancer Res.	2005

Participants

Input

Output

p-S15,S20-TP53 Tetramer:PLK3 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-02)

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