The complex of TP53-regulated inhibitor of apoptosis 1 (TRIAP1) and mitochondrial PRELI domain-containing protein 1 PRELID1 (TRIAP1:PRELID1) facilitates transport of phosphatidic acid (PA) from the outer mitochondrial membrane to the inner mitochondrial membrane. At the inner mitochondrial membrane, the PA is used for the synthesis of cardiolipin (CL). CL prevents the release of cytochrome C from mitochondria, thus playing an anti-apoptotic role (Potting et al. 2013). The complex between TRIAP1 and PRELI domain containing protein 3A (PRELID3A) is suggested to perform the same PA transport activity (Miliara et al. 2015)
Tatsuta, T, Matthews, S, Yague, E, Simpson, P, Miliara, X, Pérez-Dorado, I, Garnett, JA, Langer, T, Baldie, H, Abid Ali, F
Tatsuta, T, König, T, Aaltonen, MJ, Langer, T, Wai, T, Potting, C, Haag, M
lipid transporter activity of TRIAP1:PRELID1, PRELID3A [mitochondrial intermembrane space]
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