Reactome | TRIAP1 binds PRELID1, PRELID3A

TRIAP1 binds PRELID1, PRELID3A

Stable Identifier

R-HSA-6801242

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)

General

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In the mitochondrial intermembrane space, TP53-regulated inhibitor of apoptosis 1 (TRIAP1) forms a complex with mitochondrial PRELI domain-containing protein 1 (PRELID1, PRELI) (Potting et al. 2013). TRIAP1 is also proposed to form a complex with PRELI domain containing protein 3A (PRELID3A) (Miliara et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
23931759	TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid Potting, C, Tatsuta, T, König, T, Haag, M, Wai, T, Aaltonen, MJ, Langer, T	Cell Metab.	2013
26071602	Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes Miliara, X, Garnett, JA, Tatsuta, T, Abid Ali, F, Baldie, H, Pérez-Dorado, I, Simpson, P, Yague, E, Langer, T, Matthews, S	EMBO Rep.	2015