HC23,45-HMGB1:LPS [extracellular region]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Analysis of LPS binding to HMGB1 was conducted using a surface plasmon resonance analyses (BIAcore) and ELISA test with LPS-immobilized microtiter wells (Youn JH et al. 2008). Pull-down assays using streptavidin agarose beads and ELISA assay were conducted to map regions within the A and B box domains of HMGB1 that bind to the polysaccharide and lipid A moieties of LPS respectively (Youn JH et al. 2011).

Literature References
PubMed ID Title Journal Year
21660935 Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

Choi, JE, Wu, J, Youn, JH, Min, HJ, Shin, JS, Ji, Y, Kwak, MS, Kim, ES, Yoo, JH, Cho, HS

Eur. J. Immunol. 2011
18354232 High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes

Choi, JE, Youn, JH, Shin, JS, Kim, ES, Oh, YJ

J. Immunol. 2008
Inferred To
Cite Us!