Reactome | TP53 stimulates TRIAP1 expression

TP53 stimulates TRIAP1 expression

Stable Identifier

R-HSA-6801213

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, mitochondrial intermembrane space

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates TRIAP1 expression (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element in the second intron of the TRIAP1 (TP53-regulated inhibitor of apoptosis, also known as p53 survival factor or p53CSV) gene induces TRIAP1 transcription (Park and Nakamura 2005). Recently, TRIAP1 has been characterized as a gene-specific repressor of p21 (CDKN1A). TRIAP1 knockdown leads to augmented p21 expression before and during p53 activation and thus slows down cell proliferation (Andrysik et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
15735003	p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway Park, WR, Nakamura, Y	Cancer Res.	2005
23684607	A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation Andrysik, Z, Kim, J, Tan, AC, Espinosa, JM	Cell Rep	2013