Binding of TP53 (p53) to the p53 response element in the second intron of the TRIAP1 (TP53-regulated inhibitor of apoptosis, also known as p53 survival factor or p53CSV) gene induces TRIAP1 transcription (Park and Nakamura 2005). Recently, TRIAP1 has been characterized as a gene-specific repressor of p21 (CDKN1A). TRIAP1 knockdown leads to augmented p21 expression before and during p53 activation and thus slows down cell proliferation (Andrysik et al. 2013).
Tan, AC, Kim, J, Espinosa, JM, Andrysik, Z
Nakamura, Y, Park, WR
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