TP53 stimulates TRIAP1 expression

Stable Identifier
R-HSA-6801213
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial intermembrane space
ReviewStatus
5/5
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TP53 stimulates TRIAP1 expression
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Binding of TP53 (p53) to the p53 response element in the second intron of the TRIAP1 (TP53-regulated inhibitor of apoptosis, also known as p53 survival factor or p53CSV) gene induces TRIAP1 transcription (Park and Nakamura 2005). Recently, TRIAP1 has been characterized as a gene-specific repressor of p21 (CDKN1A). TRIAP1 knockdown leads to augmented p21 expression before and during p53 activation and thus slows down cell proliferation (Andrysik et al. 2013).
Literature References
PubMed ID Title Journal Year
23684607 A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation

Tan, AC, Kim, J, Espinosa, JM, Andrysik, Z

Cell Rep 2013
15735003 p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway

Nakamura, Y, Park, WR

Cancer Res. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:TRIAP1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-01)
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