TP53 stimulates STEAP3 expression

Stable Identifier
R-HSA-6801184
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, endosome membrane
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TP53 stimulates STEAP3 expression
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Binding of TP53 (p53) to the p53 response element in the promoter of the STEAP3 (TSAP6) gene promotes STEAP3 transcription (Passer et al. 2003). Tumor suppressor-activated pathway 6 (TSAP6) was initially discovered as differentially regulated following p53 activation and was later shown to be strongly activated in tumor suppression and reversion, and was hence named TSAP6. TSAP6 knockdown results in inhibition of apoptosis. TSAP6 binds to and cooperates with BNIP3L (NIX), a pro-apoptotic BH3-only BCL2-family member, and MYT1 kinase, a negative regulator of the G2/M transition (Lespagnol et al. 2008).

Literature References
PubMed ID Title Journal Year
18617898 Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

Duflaut, D, Lespagnol, A, Vidal, M, Marine, JC, Fiucci, G, Beekman, C, Amson, R, Telerman, A, Blanc, L

Cell Death Differ. 2008
12606722 The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

Roborel de Climens, A, Cans, C, Prieur, S, Passer, BJ, Susini, L, Dausset, J, Nancy-Portebois, V, Amson, R, Bouvard, V, Morchoisne, S, Fiucci, G, Telerman, A, Tuynder, M, Crible, V, Lespagnol, A, Amzallag, N, Oren, M

Proc. Natl. Acad. Sci. U.S.A. 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:STEAP3 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-30)
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