Reactome | TP53 stimulates STEAP3 expression

TP53 stimulates STEAP3 expression

Stable Identifier

R-HSA-6801184

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, endosome membrane

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates STEAP3 expression (Homo sapiens)

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Binding of TP53 (p53) to the p53 response element in the promoter of the STEAP3 (TSAP6) gene promotes STEAP3 transcription (Passer et al. 2003). Tumor suppressor-activated pathway 6 (TSAP6) was initially discovered as differentially regulated following p53 activation and was later shown to be strongly activated in tumor suppression and reversion, and was hence named TSAP6. TSAP6 knockdown results in inhibition of apoptosis. TSAP6 binds to and cooperates with BNIP3L (NIX), a pro-apoptotic BH3-only BCL2-family member, and MYT1 kinase, a negative regulator of the G2/M transition (Lespagnol et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
12606722	The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase Passer, BJ, Nancy-Portebois, V, Amzallag, N, Prieur, S, Cans, C, Roborel de Climens, A, Fiucci, G, Bouvard, V, Tuynder, M, Susini, L, Morchoisne, S, Crible, V, Lespagnol, A, Dausset, J, Oren, M, Amson, R, Telerman, A	Proc. Natl. Acad. Sci. U.S.A.	2003
18617898	Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice Lespagnol, A, Duflaut, D, Beekman, C, Blanc, L, Fiucci, G, Marine, JC, Vidal, M, Amson, R, Telerman, A	Cell Death Differ.	2008