The PIDDosome binds CASP2

Stable Identifier
R-HSA-6800798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIDD1, when phosphorylated by ATM at threonine residue T788, associates with CRADD (RAIDD), forming a multisubunit structure known as the PIDDosome (Tinel and Tschopp 2004, Ando et al. 2012). The PIDDosome binds procaspase-2 (CASP2), with CASP2 directly interacting with the CRADD subunit (Tinel and Tschopp 2004).
Literature References
PubMed ID Title Journal Year
15073321 The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

Tinel, A, Tschopp, J

Science 2004
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Sanda, T, Liu, PH, Wang, J, Look, AT, Logette, E, Bouchier-Hayes, L, Kernan, JL, Tschopp, J, Ando, K, Sidi, S

Mol. Cell 2012
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