MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG

Stable Identifier
Reaction [transition]
Homo sapiens
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Triacylglycerol (TG) is a non-polar acyl triester of glycerol and fatty acids. TG serves primarily as a reservoir of fatty acids for energy production. TG synthesis in all organisms occurs via the conserved canonical pathway known as the Kennedy or sn-glycerol-3-phosphate (G3P) pathway. Diacylglycerol (DAG), an intermediate in the Kennedy pathway, can also enter this pathway via an alternative route known as the remodeling pathway which dominates in the small intestine where most dietary fat is absorbed. In this pathway, monoacylglycerol is acylated, mediated by monoacylglycerol acyltransferases 1, 2 and 3 (MOGAT1, 2 and 3) to form DAG (Winter et al. 2003, Lockwood et al. 2003, Cheng et al. 2003, Yu et al. 2015).
Literature References
PubMed ID Title Journal Year
12824082 Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity

Lockwood, JF, Shi, Y, Cao, J, Burn, P

Am. J. Physiol. Endocrinol. Metab. 2003
14970677 Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals

Bininda-Emonds, OR, Fries, R, Winter, A, van Eckeveld, M, Habermann, FA

Cytogenet. Genome Res. 2003
25838202 Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation

Choi, Y, Seok, JW, Yu, JH, Kim, HJ, Lee, YJ, Choi, H, Kim, JW

Biochem. Biophys. Res. Commun. 2015
12618427 Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption

Billheimer, JT, Taub, R, Cheng, D, Nelson, TC, Wardwell-Swanson, J, Ramaker, M, Meegalla, R, Walker, SG, Feder, JN, Chen, J

J. Biol. Chem. 2003
Catalyst Activity

2-acylglycerol O-acyltransferase activity of MOGAT1,2,3 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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