MST1 binds MST1R

Stable Identifier
R-HSA-6800315
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The receptor tyrosine kinase macrophage stimulating 1 receptor (MST1R, aka recepteur d'origine nantais, RON) is the cell surface receptor for macrophage stimulating protein 1 (MST1, aka MSP) (Wang et al. 1997). Like their ligands, MST1R (and MET) is a cleaved disulfide-linked heterodimer, the mature receptor consisting of alpha and beta chains. The MST1/MST1R pathway is involved in several important biological processes, including macrophage activity, wound healing, and epithelial cell behaviour (Kretschmann et al. 2010). MST1 binding to MST1R promotes receptor dimerisation followed by receptor autophosphorylation.
Literature References
PubMed ID Title Journal Year
9202013 Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain

Takehara, T, Hagiya, M, Leonard, EJ, Yoshikawa, W, Godowski, PJ, Julian, FM, Breathnach, R, Wang, MH

J. Biol. Chem. 1997
20545605 The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression

Kretschmann, KL, Buys, SS, Eyob, H, Welm, AL

Curr Drug Targets 2010
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!