MST1 binds MST1R

Stable Identifier
R-HSA-6800315
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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MST1 binds MST1R
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The receptor tyrosine kinase macrophage stimulating 1 receptor (MST1R, aka recepteur d'origine nantais, RON) is the cell surface receptor for macrophage stimulating protein 1 (MST1, aka MSP) (Wang et al. 1997). Like their ligands, MST1R (and MET) is a cleaved disulfide-linked heterodimer, the mature receptor consisting of alpha and beta chains. The MST1/MST1R pathway is involved in several important biological processes, including macrophage activity, wound healing, and epithelial cell behaviour (Kretschmann et al. 2010). MST1 binding to MST1R promotes receptor dimerisation followed by receptor autophosphorylation.

Literature References
PubMed ID Title Journal Year
20545605 The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression

Kretschmann, KL, Eyob, H, Buys, SS, Welm, AL

Curr Drug Targets 2010
9202013 Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain

Wang, MH, Julian, FM, Breathnach, R, Godowski, PJ, Takehara, T, Yoshikawa, W, Hagiya, M, Leonard, EJ

J. Biol. Chem. 1997
Participants
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Output
Participant Of
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Authored
Jassal, B  (2015-09-29)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-29)