Reactome | MST1 binds MST1R

MST1 binds MST1R

Stable Identifier

R-HSA-6800315

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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The receptor tyrosine kinase macrophage stimulating 1 receptor (MST1R, aka recepteur d'origine nantais, RON) is the cell surface receptor for macrophage stimulating protein 1 (MST1, aka MSP) (Wang et al. 1997). Like their ligands, MST1R (and MET) is a cleaved disulfide-linked heterodimer, the mature receptor consisting of alpha and beta chains. The MST1/MST1R pathway is involved in several important biological processes, including macrophage activity, wound healing, and epithelial cell behaviour (Kretschmann et al. 2010). MST1 binding to MST1R promotes receptor dimerisation followed by receptor autophosphorylation.

Literature References

PubMed ID	Title	Journal	Year
9202013	Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain Wang, MH, Julian, FM, Breathnach, R, Godowski, PJ, Takehara, T, Yoshikawa, W, Hagiya, M, Leonard, EJ	J. Biol. Chem.	1997
20545605	The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression Kretschmann, KL, Eyob, H, Buys, SS, Welm, AL	Curr Drug Targets	2010