SREBP1A,1C binds the SCD gene

Stable Identifier
R-HSA-6800052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SREBP1A,1C binds the SCD gene
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SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the Stearoyl CoA Desaturase 1 (SCD1) gene and enhance transcription (Pai et al. 1998, Shimao et al. 1999, Tabor et al. 1999, Bene et al. 2001, reviewed in Horton et al. 2002).
Literature References
PubMed ID Title Journal Year
10400691 Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

Tabor, DE, Kim, JB, Spiegelman, BM, Edwards, PA

J Biol Chem 1999
18654640 Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes

Reed, BD, Charos, AE, Szekely, AM, Weissman, SM, Snyder, M

PLoS Genet 2008
11414710 Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol

Bené, H, Lasky, D, Ntambi, JM

Biochem Biophys Res Commun 2001
10585467 Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

Shimano, H, Yahagi, N, Amemiya-Kudo, M, Hasty, AH, Osuga, J, Tamura, Y, Shionoiri, F, Iizuka, Y, Ohashi, K, Harada, K, Gotoda, T, Ishibashi, S, Yamada, N

J Biol Chem 1999
11994399 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, JD, Goldstein, JL, Brown, MS

J Clin Invest 2002
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Authored
May, B  (2015-09-27)
Reviewed
May, B  (2015-09-27)
Created
May, B  (2015-09-27)
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