TP53 stimulates IGFBP3 expression

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R-HSA-6800044
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Reaction [omitted]
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Homo sapiens
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Binding of TP53 (p53) to p53 response elements in the first and second introns of the IGFBP3 gene upregulates IGFBP3 transcription (Buckbinder et al. 1995). IGFBP3 is one of a family of six homologous proteins that bind IGF1 and IGF2 with high affinity. IGFBP3 contributes to cellular apoptosis in both IGF-dependent and IGF-independent manner (Marzec et al. 2015).

Literature References
PubMed ID Title Journal Year
26378048 Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage

Marzec, KA, Lin, MZ, Martin, JL, Baxter, RC

Oncotarget 2015
7566179 Induction of the growth inhibitor IGF-binding protein 3 by p53

Buckbinder, L, Talbott, R, Velasco-Miguel, S, Takenaka, I, Faha, B, Seizinger, BR, Kley, N

Nature 1995
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