TP53 stimulates IGFBP3 expression

Stable Identifier
R-HSA-6800044
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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TP53 stimulates IGFBP3 expression
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Binding of TP53 (p53) to p53 response elements in the first and second introns of the IGFBP3 gene upregulates IGFBP3 transcription (Buckbinder et al. 1995). IGFBP3 is one of a family of six homologous proteins that bind IGF1 and IGF2 with high affinity. IGFBP3 contributes to cellular apoptosis in both IGF-dependent and IGF-independent manner (Marzec et al. 2015).

Literature References
PubMed ID Title Journal Year
7566179 Induction of the growth inhibitor IGF-binding protein 3 by p53

Seizinger, BR, Faha, B, Talbott, R, Buckbinder, L, Takenaka, I, Kley, N, Velasco-Miguel, S

Nature 1995
26378048 Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage

Martin, JL, Lin, MZ, Marzec, KA, Baxter, RC

Oncotarget 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:IGFBP3 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-26)
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