TP53 binds the IGFBP3 gene

Stable Identifier
R-HSA-6800042
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 binds the IGFBP3 gene
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TP53 (p53) binds p53 response elements in the first and second introns of the IGFBP3 gene and promotes its upregulation (Buckbinder et al. 1995). In response to DNA damage and hypoxia, IGFBP3 can also be upregulated in a p53-independent manner (Grimberg et al. 2005).

Literature References
PubMed ID Title Journal Year
7566179 Induction of the growth inhibitor IGF-binding protein 3 by p53

Seizinger, BR, Faha, B, Talbott, R, Buckbinder, L, Takenaka, I, Kley, N, Velasco-Miguel, S

Nature 1995
15769996 p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia

Coleman, CM, Cohen, P, Koch, CJ, Himelstein, BP, Burns, TF, El-Deiry, WS, Grimberg, A

J. Clin. Endocrinol. Metab. 2005
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Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-26)
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