IGFBP3 binds TMEM219

Stable Identifier
R-HSA-6800035
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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IGFBP3 binds TMEM219
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IGFBP3 binds a cell death receptor TMEM219 (IGFBP-3R), a single-span transmembrane protein. Activated TMEM219 can trigger apoptosis, probably by directly binding to and activating caspase-8 (CASP8) (Ingermann et al. 2010).

Literature References
PubMed ID Title Journal Year
20353938 Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer

Ingermann, AR, Yang, YF, Han, J, Mikami, A, Garza, AE, Mohanraj, L, Fan, L, Idowu, M, Ware, JL, Kim, HS, Lee, DY, Oh, Y

J. Biol. Chem. 2010
Participants
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Orthologous Events
IGFBP3 binds TMEM219 (Bos taurus)
IGFBP3 binds TMEM219 (Canis familiaris)
IGFBP3 binds TMEM219 (Danio rerio)
IGFBP3 binds TMEM219 (Mus musculus)
IGFBP3 binds TMEM219 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-26)