IGFBP3 binds a cell death receptor TMEM219 (IGFBP-3R), a single-span transmembrane protein. Activated TMEM219 can trigger apoptosis, probably by directly binding to and activating caspase-8 (CASP8) (Ingermann et al. 2010).
Ingermann, AR, Yang, YF, Han, J, Mikami, A, Garza, AE, Mohanraj, L, Fan, L, Idowu, M, Ware, JL, Kim, HS, Lee, DY, Oh, Y
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