IGFBP3 binds TMEM219

Stable Identifier
R-HSA-6800035
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IGFBP3 binds TMEM219
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
IGFBP3 binds a cell death receptor TMEM219 (IGFBP-3R), a single-span transmembrane protein. Activated TMEM219 can trigger apoptosis, probably by directly binding to and activating caspase-8 (CASP8) (Ingermann et al. 2010).
Literature References
PubMed ID Title Journal Year
20353938 Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer

Kim, HS, Ware, JL, Garza, AE, Mikami, A, Han, J, Ingermann, AR, Idowu, M, Lee, DY, Yang, YF, Oh, Y, Fan, L, Mohanraj, L

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
IGFBP3 binds TMEM219 (Bos taurus)
IGFBP3 binds TMEM219 (Danio rerio)
IGFBP3 binds TMEM219 (Mus musculus)
IGFBP3 binds TMEM219 (Rattus norvegicus)
IGFBP3 binds TMEM219 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-26)
Cite Us!