IGFBP3 binds a cell death receptor TMEM219 (IGFBP-3R), a single-span transmembrane protein. Activated TMEM219 can trigger apoptosis, probably by directly binding to and activating caspase-8 (CASP8) (Ingermann et al. 2010).
Kim, HS, Ware, JL, Garza, AE, Mikami, A, Han, J, Ingermann, AR, Idowu, M, Lee, DY, Yang, YF, Oh, Y, Fan, L, Mohanraj, L
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