IGFBP3 binds TMEM219

Stable Identifier
R-HSA-6800035
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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IGFBP3 binds TMEM219
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IGFBP3 binds a cell death receptor TMEM219 (IGFBP-3R), a single-span transmembrane protein. Activated TMEM219 can trigger apoptosis, probably by directly binding to and activating caspase-8 (CASP8) (Ingermann et al. 2010).

Literature References
PubMed ID Title Journal Year
20353938 Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer

Kim, HS, Ware, JL, Garza, AE, Mikami, A, Han, J, Ingermann, AR, Idowu, M, Lee, DY, Yang, YF, Oh, Y, Fan, L, Mohanraj, L

J. Biol. Chem. 2010
Participants
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Output
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as an event of
Orthologous Events
IGFBP3 binds TMEM219 (Danio rerio)
IGFBP3 binds TMEM219 (Mus musculus)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-26)
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