Reactome | TP53 family members stimulate FAS gene expression

TP53 family members stimulate FAS gene expression

Stable Identifier

R-HSA-6800001

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm, plasma membrane

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)

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TP53 family members stimulate FAS gene expression

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The p53 family members TP53 (p53), TP63 (p63), or TP73 (p73), most likely in complex with ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) (Wilson et al. 2013), bind p53 response elements in the first intron and/or promoter of the FAS gene, promoting FAS transcription (Schilling et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
23365256	ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo Feinstein, E, Wilson, AM, Morquette, B, Abdouh, M, Bernier, G, Unsain, N, Di Polo, A, Barker, PA	J. Neurosci.	2013
19615968	Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family Müller, M, Schleithoff, ES, Melino, G, Kairat, A, Schilling, T, Stremmel, W, Krammer, PH, Oren, M	Biochem. Biophys. Res. Commun.	2009