TP53 family members stimulate FAS gene expression

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The p53 family members TP53 (p53), TP63 (p63), or TP73 (p73), most likely in complex with ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) (Wilson et al. 2013), bind p53 response elements in the first intron and/or promoter of the FAS gene, promoting FAS transcription (Schilling et al. 2009).

Literature References
PubMed ID Title Journal Year
19615968 Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

Schilling, T, Schleithoff, ES, Kairat, A, Melino, G, Stremmel, W, Oren, M, Krammer, PH, Müller, M

Biochem. Biophys. Res. Commun. 2009
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A

J. Neurosci. 2013
Participant Of
This event is regulated
Cite Us!