The FAS gene possesses three p53 response elements in the promoter and one p53 response element in its first intron. TP53 family members TP53 (p53), TP63 (p63) and TP73 (p73) can all bind the intronic p53 response element and activate FAS gene transcription. The promoter p53 response elements also contribute to the transcriptional activation of FAS (Schilling et al. 2009). The complex of TP53 (or, probably, TP63 or TP73) with ASSP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) enhances FAS transcription (Wilson et al. 2013). FAS interacts with its natural ligand, CD95L, a member of the TNF cytokine family, to initiate the death signal cascade, which results in programmed cell death. FAS can function as a guardian against autoimmunity and tumor development (Schilling et al. 2009).
Schilling, T, Schleithoff, ES, Kairat, A, Melino, G, Stremmel, W, Oren, M, Krammer, PH, Müller, M
Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A
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