GPX5,6 reduce H2O2 to H2O

Stable Identifier
R-HSA-6799695
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GPX5,6 reduce H2O2 to H2O
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Epididymal secretory glutathione peroxidase (GPX5), a secreted and selenium-independent isoform of glutathione peroxidases, is present in very low levels in human sperm ejaculate. GPX5 has the potential to reduce hydrogen peroxide (H2O2) using glutathione (GSH), based on activity observed in rat and pig forms of the enzyme but its role in human epidydimis is unknown (Hall et al. 1998). Glutathione peroxidase 6 (GPX6) is thought to have peroxidase activity based on sequence similarity to GPX5.

Literature References
PubMed ID Title Journal Year
9639555 The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract

Hall, L, Williams, K, Perry, AC, Frayne, J, Jury, JA

Biochem. J. 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX5, (GPX6) [extracellular region]
Physical Entity
GPX5, (GPX6) [extracellular region]
Activity
glutathione peroxidase activity (0004602)
Orthologous Events
GPX5,6 reduce H2O2 to H2O (Bos taurus)
GPX5,6 reduce H2O2 to H2O (Caenorhabditis elegans)
GPX5,6 reduce H2O2 to H2O (Danio rerio)
GPX5,6 reduce H2O2 to H2O (Gallus gallus)
GPX5,6 reduce H2O2 to H2O (Mus musculus)
GPX5,6 reduce H2O2 to H2O (Rattus norvegicus)
GPX5,6 reduce H2O2 to H2O (Sus scrofa)
Authored
Jassal, B  (2015-09-25)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-25)
Cite Us!