Reactome | MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5

MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5

Stable Identifier

R-HSA-6799545

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5

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Endoplasmic reticulum-associated degradation of misfolded glycoproteins ensures only functional, correctly folded proteins exit from the endoplasmic reticulum and that misfolded ones are targeted for lysosomal degradation. Misfolded glycoproteins are deglycosylated in the cytosol and the resultant free oligosaccharide can be further hydrolysed by alpha-mannosidase 2C1 (MAN2C1). For example, the oligosaccharide structure GlcNAc (Man)9 is hydrolysed by MAN2C1 to GlcNAc (Man)5, an intermediate structure formed in the N-glycan precursor biosynthesis pathway (Suzuki et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16848760	Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol Funakoshi, Y, Nakano, M, Hara, I, Taniguchi, N, Shigeta, M, Kondo, A, Nakagawa, T, Suzuki, T	Biochem. J.	2006