MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5

Stable Identifier
R-HSA-6799545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Endoplasmic reticulum-associated degradation of misfolded glycoproteins ensures only functional, correctly folded proteins exit from the endoplasmic reticulum and that misfolded ones are targeted for lysosomal degradation. Misfolded glycoproteins are deglycosylated in the cytosol and the resultant free oligosaccharide can be further hydrolysed by alpha-mannosidase 2C1 (MAN2C1). For example, the oligosaccharide structure GlcNAc (Man)9 is hydrolysed by MAN2C1 to GlcNAc (Man)5, an intermediate structure formed in the N-glycan precursor biosynthesis pathway (Suzuki et al. 2006).

Literature References
PubMed ID Title Journal Year
16848760 Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol

Suzuki, T, Hara, I, Nakano, M, Shigeta, M, Nakagawa, T, Kondo, A, Funakoshi, Y, Taniguchi, N

Biochem. J. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-mannosidase activity of MAN2C1:Zn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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Created