TP53 binds HIPK1

Stable Identifier
R-HSA-6799431
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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TP53 (p53) forms a complex with a protein kinase HIPK1 (Kondo et al. 2003, Rey et al. 2013). HIPK1 may phosphorylate TP53 on an unidentified serine residue (Kondo et al. 2003). Binding to HIPK1 has been implicated in the negative regulation of TP53 activity (Kondo et al. 2003), but HIPK1 overexpression has also been implicated in the positive regulation of TP53 activity (Rey et al. 2013).

Literature References
PubMed ID Title Journal Year
12702766 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)

Kondo, S, Lu, Y, Debbas, M, Lin, AW, Sarosi, I, Itie, A, Wakeham, A, Tuan, J, Saris, C, Elliott, G, Ma, W, Benchimol, S, Lowe, SW, Mak, TW, Thukral, SK

Proc. Natl. Acad. Sci. U.S.A. 2003
23676219 HIPK1 drives p53 activation to limit colorectal cancer cell growth

Rey, C, Soubeyran, I, Mahouche, I, Pedeboscq, S, Bessede, A, Ichas, F, De Giorgi, F, Lartigue, L

Cell Cycle 2013
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created