TP53 binds HIPK1

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) forms a complex with a protein kinase HIPK1 (Kondo et al. 2003, Rey et al. 2013). HIPK1 may phosphorylate TP53 on an unidentified serine residue (Kondo et al. 2003). Binding to HIPK1 has been implicated in the negative regulation of TP53 activity (Kondo et al. 2003), but HIPK1 overexpression has also been implicated in the positive regulation of TP53 activity (Rey et al. 2013).

Literature References
PubMed ID Title Journal Year
12702766 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)

Kondo, S, Lu, Y, Debbas, M, Lin, AW, Sarosi, I, Itie, A, Wakeham, A, Tuan, J, Saris, C, Elliott, G, Ma, W, Benchimol, S, Lowe, SW, Mak, TW, Thukral, SK

Proc. Natl. Acad. Sci. U.S.A. 2003
23676219 HIPK1 drives p53 activation to limit colorectal cancer cell growth

Rey, C, Soubeyran, I, Mahouche, I, Pedeboscq, S, Bessede, A, Ichas, F, De Giorgi, F, Lartigue, L

Cell Cycle 2013
Participant Of
Orthologous Events
Cite Us!