TP53 binds HIPK1

Stable Identifier
R-HSA-6799431
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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TP53 binds HIPK1
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TP53 (p53) forms a complex with a protein kinase HIPK1 (Kondo et al. 2003, Rey et al. 2013). HIPK1 may phosphorylate TP53 on an unidentified serine residue (Kondo et al. 2003). Binding to HIPK1 has been implicated in the negative regulation of TP53 activity (Kondo et al. 2003), but HIPK1 overexpression has also been implicated in the positive regulation of TP53 activity (Rey et al. 2013).

Literature References
PubMed ID Title Journal Year
12702766 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)

Kondo, S, Lu, Y, Debbas, M, Lin, AW, Sarosi, I, Itie, A, Wakeham, A, Tuan, J, Saris, C, Elliott, G, Ma, W, Benchimol, S, Lowe, SW, Mak, TW, Thukral, SK

Proc. Natl. Acad. Sci. U.S.A. 2003
23676219 HIPK1 drives p53 activation to limit colorectal cancer cell growth

Rey, C, Soubeyran, I, Mahouche, I, Pedeboscq, S, Bessede, A, Ichas, F, De Giorgi, F, Lartigue, L

Cell Cycle 2013
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
TP53 binds HIPK1 (Bos taurus)
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TP53 binds HIPK1 (Mus musculus)
TP53 binds HIPK1 (Rattus norvegicus)
TP53 binds HIPK1 (Sus scrofa)
TP53 binds HIPK1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-24)