Reactome | TP53 binds HIPK1

TP53 binds HIPK1

Stable Identifier

R-HSA-6799431

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        TP53 binds HIPK1 (Homo sapiens)

General

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TP53 (p53) forms a complex with a protein kinase HIPK1 (Kondo et al. 2003, Rey et al. 2013). HIPK1 may phosphorylate TP53 on an unidentified serine residue (Kondo et al. 2003). Binding to HIPK1 has been implicated in the negative regulation of TP53 activity (Kondo et al. 2003), but HIPK1 overexpression has also been implicated in the positive regulation of TP53 activity (Rey et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23676219	HIPK1 drives p53 activation to limit colorectal cancer cell growth Soubeyran, I, Lartigue, L, Pedeboscq, S, Rey, C, Bessede, A, Ichas, F, De Giorgi, F, Mahouche, I	Cell Cycle	2013
12702766	Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) Lowe, SW, Itie, A, Lu, Y, Ma, W, Kondo, S, Benchimol, S, Debbas, M, Mak, TW, Wakeham, A, Lin, AW, Elliott, G, Thukral, SK, Sarosi, I, Saris, C, Tuan, J	Proc. Natl. Acad. Sci. U.S.A.	2003