ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex

Stable Identifier
R-HSA-6799199
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
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ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
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Membrane arm subunits MT-ND2, 3 and 6 and NDUFB6 associate with the assembly factors TMEM126B, NDUFAF1, ECSIT and ACAD9 (which form the MCIA complex) forming a 370kDa subcomplex (Mckenzie & Ryan 2010, Andrews et al. 2013).

Literature References
PubMed ID Title Journal Year
24191001 Assembly factors for the membrane arm of human complex I

Andrews, B, Carroll, J, Ding, S, Fearnley, IM, Walker, JE

Proc. Natl. Acad. Sci. U.S.A. 2013
20552642 Assembly factors of human mitochondrial complex I and their defects in disease

McKenzie, M, Ryan, MT

IUBMB Life 2010
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Orthologous Events
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Canis familiaris)
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Danio rerio)
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Gallus gallus)
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Mus musculus)
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Rattus norvegicus)
ND2, ND3, ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Xenopus tropicalis)
Authored
Jassal, B  (2015-09-22)
Reviewed
Meldal, BH  (2015-10-01)
Created
Jassal, B  (2015-09-22)