Reactome | ND4, ND5 bind the 550kDa complex to form the 815kDa complex

ND4, ND5 bind the 550kDa complex to form the 815kDa complex

Stable Identifier

R-HSA-6799197

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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ND4, ND5 bind the 550kDa complex to form the 815kDa complex

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Distal components of the membrane arm MT-ND4 and 5 associate with the 550kDa complex to form the 815kDa complex (Mckenzie & Ryan 2010, Andrews et al. 2013). Distal membrane-arm assembly complex proteins 1 and 2 (DMAC1, DMAC2) are required for the integration of ND4 and ND5. Knockout of DMAC1 or DMAC2 led to severe Complex I deficiency in HEK293T cells (Stroud et al., 2016).

Literature References

PubMed ID	Title	Journal	Year
27626371	Accessory subunits are integral for assembly and function of human mitochondrial complex I Stroud, DA, Surgenor, EE, Formosa, LE, Reljic, B, Frazier, AE, Dibley, MG, Osellame, LD, Stait, T, Beilharz, TH, Thorburn, DR, Salim, A, Ryan, MT	Nature	2016
20552642	Assembly factors of human mitochondrial complex I and their defects in disease McKenzie, M, Ryan, MT	IUBMB Life	2010
24191001	Assembly factors for the membrane arm of human complex I Andrews, B, Carroll, J, Ding, S, Fearnley, IM, Walker, JE	Proc. Natl. Acad. Sci. U.S.A.	2013