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Exocytosis of specific granule lumen proteins
Stable Identifier
R-HSA-6798749
Type
Reaction [transition]
Species
Homo sapiens
Compartment
specific granule lumen
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
General
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Secondary (specific) granules are peroxidase-negative and rich in antimicrobial substances (Joiner et al. 1989, Rorvig et al. 2012). They are more irregular and elongated in form than azurophil granules (Bainton et al. 1971). This might reflect volume adjustment in azurophil granules, which are known to proteolytically process a significant fraction of the proteins that are targeted to them, while little or no processing and therefore no increase in osmotic activity due to proteolysis has been observed in secondary granules (Borregaard & Cowland 1997). Secondary and tertiary granules have overlapping contents but can be discriminated by their intrinsic buoyant densities when centrifuged on gradient media (Kjeldsen et al. 1994).
Literature References
PubMed ID
Title
Journal
Year
23650620
Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors
Heegaard, NH
,
Rørvig, S
,
Borregaard, N
,
Østergaard, O
J. Leukoc. Biol.
2013
Participants
Input
Specific granule lumen proteins [specific granule lumen]
(Homo sapiens)
Output
Specific granule lumen proteins [extracellular region]
(Homo sapiens)
Participates
as an event of
Neutrophil degranulation (Homo sapiens)
Orthologous Events
Exocytosis of specific granule lumen proteins (Bos taurus)
Exocytosis of specific granule lumen proteins (Caenorhabditis elegans)
Exocytosis of specific granule lumen proteins (Canis familiaris)
Exocytosis of specific granule lumen proteins (Danio rerio)
Exocytosis of specific granule lumen proteins (Dictyostelium discoideum)
Exocytosis of specific granule lumen proteins (Drosophila melanogaster)
Exocytosis of specific granule lumen proteins (Gallus gallus)
Exocytosis of specific granule lumen proteins (Mus musculus)
Exocytosis of specific granule lumen proteins (Plasmodium falciparum)
Exocytosis of specific granule lumen proteins (Rattus norvegicus)
Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)
Exocytosis of specific granule lumen proteins (Schizosaccharomyces pombe)
Exocytosis of specific granule lumen proteins (Sus scrofa)
Exocytosis of specific granule lumen proteins (Xenopus tropicalis)
Authored
Jupe, S (2015-09-21)
Reviewed
Heegaard, N (2016-06-13)
Created
Jupe, S (2015-09-21)
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