Reactome | Exocytosis of secretory granule membrane proteins

Exocytosis of secretory granule membrane proteins

Stable Identifier

R-HSA-6798743

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, secretory granule membrane

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Exocytosis of secretory granule membrane proteins

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Secretory vesicles provide a reservoir of membrane-associated receptors that are required at the earliest stages of the neutrophil-mediated inflammatory response. They are mobilized in response to a wide variety of inflammatory stimuli (Sengelov et al. 1993a,b). Resultant cell surface changes allow the neutrophil to establish firm contact with activated vascular epithelium (Faurschou & Borregaard 2003).

Literature References

PubMed ID	Title	Journal	Year
23650620	Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors Rørvig, S, Østergaard, O, Heegaard, NH, Borregaard, N	J. Leukoc. Biol.	2013