Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific trifunctional enzyme. One of its functions is the isomerisation of 1,3-bisphosphoglycerate (1,3BPG) to 2,3-bisphosphoglycerate (2,3BPG) (Rose 1968). In red blood cells, 2,3BPG is the main allosteric effector of hemoglobin, binding preferentially to the deoxygenated hemoglobin tetramer, thus reducing oxygen affinity (Arnone 1972).
Arnone, A
Rose, ZB
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