BPGM dimer isomerises 1,3BPG to 2,3BPG

Stable Identifier
R-HSA-6798335
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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BPGM dimer isomerises 1,3BPG to 2,3BPG
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Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific trifunctional enzyme. One of its functions is the isomerisation of 1,3-bisphosphoglycerate (1,3BPG) to 2,3-bisphosphoglycerate (2,3BPG) (Rose 1968). In red blood cells, 2,3BPG is the main allosteric effector of hemoglobin, binding preferentially to the deoxygenated hemoglobin tetramer, thus reducing oxygen affinity (Arnone 1972).

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Participant Of
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Event Information
Go Biological Process
carbohydrate derivative catabolic process (1901136)
Catalyst Activity
Catalyst Activity
Title
bisphosphoglycerate mutase activity of BPGM dimer [cytosol]
Physical Entity
BPGM dimer [cytosol]
Activity
bisphosphoglycerate mutase activity (0004082)
Orthologous Events
BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Gallus gallus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Schizosaccharomyces pombe)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)
Authored
Jassal, B  (2015-09-18)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-18)