TP53 and E2F4 bind the CDC25C gene

Stable Identifier
R-HSA-6798282
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 and E2F4 bind the CDC25C gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The promoter of the CDC25C gene contains p53 response elements as well as E2F binding sites and can bind both TP53 (St Clair et al. 2004) and E2F4 (Benson et al. 2014). E2F4 transcription repressor complex consists of E2F4, a transcriptional co-factor TFDP1 (DP1) or TFDP2 (DP2), and a retinoblastoma family protein RBL1 (p107) or RBL2 (p130). The CDK inhibitor p21 (CDKN1A), induced by TP53, positively affects E2F4 recruitment to the CDC25C promoter, probably by upregulating RBL2 (Helmbold et al. 2009, Benson et al. 2014).

Literature References
PubMed ID Title Journal Year
24096481 p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

Manfredi, JJ, Attie, O, Aaronson, SA, Kracikova, M, Benson, EK, Sachidanandam, R, Mungamuri, SK

Oncogene 2014
15574328 DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter

Manfredi, JJ, St Clair, S, Mattia, M, Varmeh-Ziaie, S, Liu, WJ, Giono, L, DaCosta, A, Padi, A, Resnick-Silverman, L, Dastidar, J

Mol. Cell 2004
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-17)
Cite Us!