Reactome | TP53 and E2F4 inhibit CDC25C expression

TP53 and E2F4 inhibit CDC25C expression

Stable Identifier

R-HSA-6798268

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)

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Binding of TP53 and the E2F4 repressor complex to the promoter of the CDC25C gene results in the inhibition of CDC25C transcription, an important step in the maintenance of the G2 cell cycle checkpoint (St. Clair et al. 2004, Benson et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24096481	p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes Manfredi, JJ, Attie, O, Aaronson, SA, Kracikova, M, Benson, EK, Sachidanandam, R, Mungamuri, SK	Oncogene	2014
15574328	DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter Manfredi, JJ, St Clair, S, Mattia, M, Varmeh-Ziaie, S, Liu, WJ, Giono, L, DaCosta, A, Padi, A, Resnick-Silverman, L, Dastidar, J	Mol. Cell	2004