TP53 stimulates CASP10 expression

Stable Identifier
R-HSA-6798139
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates CASP10 expression
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Upon binding to p53 response elements at the CASP10 (caspase-10) gene locus, TP53 (p53) stimulates CASP10 expression (Rikhof et al. 2003). CASP10 is involved in apoptosis triggered by death receptor signaling (Wang et al. 2001, Sprick et al. 2002).

Literature References
PubMed ID Title Journal Year
11717445 Caspase-10 is an initiator caspase in death receptor signaling

Wong, W, Spencer, DM, Chun, HJ, Wang, J, Lenardo, MJ

Proc Natl Acad Sci U S A 2001
14688482 Caspase 10 levels are increased following DNA damage in a p53-dependent manner

Rikhof, B, Corn, PG, El-Deiry, WS

Cancer Biol. Ther. 2003
12198154 Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

Stahl, H, Weigand, MA, Grosse-Wilde, A, Sprick, MR, Rieser, E, Walczak, H

EMBO J 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:CASP10 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-17)
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