TP53 stimulates CASP10 expression

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Reaction [omitted]
Homo sapiens
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Upon binding to p53 response elements at the CASP10 (caspase-10) gene locus, TP53 (p53) stimulates CASP10 expression (Rikhof et al. 2003). CASP10 is involved in apoptosis triggered by death receptor signaling (Wang et al. 2001, Sprick et al. 2002).

Literature References
PubMed ID Title Journal Year
14688482 Caspase 10 levels are increased following DNA damage in a p53-dependent manner

Rikhof, B, Corn, PG, El-Deiry, WS

Cancer Biol. Ther. 2003
11717445 Caspase-10 is an initiator caspase in death receptor signaling

Wang, J, Chun, HJ, Wong, W, Spencer, DM, Lenardo, MJ

Proc Natl Acad Sci U S A 2001
12198154 Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

Sprick, MR, Rieser, E, Stahl, H, Grosse-Wilde, A, Weigand, MA, Walczak, H

EMBO J 2002
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