Reactome | TP53 binds the CASP6 gene

TP53 binds the CASP6 gene

Stable Identifier

R-HSA-6798129

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        TP53 binds the CASP6 gene (Homo sapiens)

General

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TP53 (p53) binds the p53 response element located in the third intron of the caspase-6 (CASP6) gene (MacLachlan and El-Deiry 2002).

Literature References

PubMed ID	Title	Journal	Year
12089322	Apoptotic threshold is lowered by p53 transactivation of caspase-6 MacLachlan, TK, El-Deiry, WS	Proc. Natl. Acad. Sci. U.S.A.	2002

Participants

Input

Output

p-S15,S20-TP53 Tetramer:CASP6 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-17)

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