TP53 stimulates CASP6 expression

Stable Identifier
R-HSA-6798126
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 stimulates CASP6 expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of TP53 (p53) to the third intron of the CASP6 (caspase-6) gene stimulates CASP6 expression (MacLachlan and El-Deiry 2002).

Literature References
PubMed ID Title Journal Year
12089322 Apoptotic threshold is lowered by p53 transactivation of caspase-6

MacLachlan, TK, El-Deiry, WS

Proc. Natl. Acad. Sci. U.S.A. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:CASP6 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-17)
Cite Us!