Reactome | TP53 stimulates BTG2 expression

TP53 stimulates BTG2 expression

Stable Identifier

R-HSA-6798031

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 stimulates BTG2 expression (Homo sapiens)

General

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Upon binding to the p53 response element in the promoter of the BTG2 gene, TP53 induces expression of BTG2 (Rouault et al. 1996, Duriez et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8944033	Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway Rouault, JP, Falette, N, Guéhenneux, F, Guillot, C, Rimokh, R, Wang, Q, Berthet, C, Moyret-Lalle, C, Savatier, P, Pain, B, Shaw, P, Berger, R, Samarut, J, Magaud, JP, Ozturk, M, Samarut, C, Puisieux, A	Nat. Genet.	1996
11814693	The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene Duriez, C, Falette, N, Audoynaud, C, Moyret-Lalle, C, Bensaad, K, Courtois, S, Wang, Q, Soussi, T, Puisieux, A	Gene	2002