TP53 stimulates BTG2 expression

Stable Identifier
R-HSA-6798031
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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TP53 stimulates BTG2 expression
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Upon binding to the p53 response element in the promoter of the BTG2 gene, TP53 induces expression of BTG2 (Rouault et al. 1996, Duriez et al. 2002).

Literature References
PubMed ID Title Journal Year
11814693 The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene

Audoynaud, C, Puisieux, A, Moyret-Lalle, C, Bensaad, K, Wang, Q, Soussi, T, Falette, N, Duriez, C, Courtois, S

Gene 2002
8944033 Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

Puisieux, A, Savatier, P, Pain, B, Guillot, C, Falette, N, Ozturk, M, Moyret-Lalle, C, Rimokh, R, Rouault, JP, Magaud, JP, Guéhenneux, F, Samarut, C, Berger, R, Wang, Q, Shaw, P, Berthet, C, Samarut, J

Nat. Genet. 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:BTG2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-16)
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