TP53 stimulates BNIP3L expression

Stable Identifier
R-HSA-6798004
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial outer membrane
ReviewStatus
5/5
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TP53 stimulates BNIP3L expression
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TP53 (p53) and CREBBP (CBP) bound to the BNIP3L gene stimulate expression of the BNIP3L. BNIP3L is an outer mitochondrial membrane protein that belongs to the BCL2 family and promotes apoptosis of cells under hypoxic stress (Fei et al. 2004).
Literature References
PubMed ID Title Journal Year
15607964 Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

Dicker, DT, Wang, W, Buzzai, M, Wang, S, McKenna, WG, Kim, SH, Fei, P, Bernhard, EJ, Sax, JK, Burns, TF, El-Deiry, WS

Cancer Cell 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:CREBBP:BNIP3L Gene [nucleoplasm] (Homo sapiens)
Active Unit
CREBBP [nucleoplasm]
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-16)
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