Reactome | TP53 and CREBBP bind BNIP3L gene

TP53 and CREBBP bind BNIP3L gene

Stable Identifier

R-HSA-6797993

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 and CREBBP bind BNIP3L gene (Homo sapiens)

General

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In hypoxic cells, TP53 (p53) binds p53 responsive elements in the BNIP3L gene. CREBBP (CBP) also localizes to the BNIP3L gene under hypoxic conditions, in vicinity to some of the p53 response elements, which is probably regulated by HIF1A (Fei et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15607964	Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth Fei, P, Wang, W, Kim, SH, Wang, S, Burns, TF, Sax, JK, Buzzai, M, Dicker, DT, McKenna, WG, Bernhard, EJ, El-Deiry, WS	Cancer Cell	2004

Participants

Input

Output

p-S15,S20-TP53 Tetramer:CREBBP:BNIP3L Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-16)

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