TP53 and CREBBP bind BNIP3L gene

Stable Identifier
R-HSA-6797993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 and CREBBP bind BNIP3L gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In hypoxic cells, TP53 (p53) binds p53 responsive elements in the BNIP3L gene. CREBBP (CBP) also localizes to the BNIP3L gene under hypoxic conditions, in vicinity to some of the p53 response elements, which is probably regulated by HIF1A (Fei et al. 2004).

Literature References
PubMed ID Title Journal Year
15607964 Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

Dicker, DT, Wang, W, Buzzai, M, Wang, S, McKenna, WG, Kim, SH, Fei, P, Bernhard, EJ, Sax, JK, Burns, TF, El-Deiry, WS

Cancer Cell 2004
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-16)
Cite Us!