TP53 and CREBBP bind BNIP3L gene

Stable Identifier
R-HSA-6797993
Type
Reaction [binding]
Species
Homo sapiens
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In hypoxic cells, TP53 (p53) binds p53 responsive elements in the BNIP3L gene. CREBBP (CBP) also localizes to the BNIP3L gene under hypoxic conditions, in vicinity to some of the p53 response elements, which is probably regulated by HIF1A (Fei et al. 2004).

Literature References
PubMed ID Title Journal Year
15607964 Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

Fei, P, Wang, W, Kim, SH, Wang, S, Burns, TF, Sax, JK, Buzzai, M, Dicker, DT, McKenna, WG, Bernhard, EJ, El-Deiry, WS

Cancer Cell 2004
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