CHDH oxidises Cho to BETALD

Stable Identifier
R-HSA-6797961
Type
Reaction
Species
Homo sapiens
Compartment
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Mitochondrial choline dehydrogenase (CHDH), located on the inner mitochondrial membrane, catalyses the oxidation of choline (Cho) to betaine aldehyde (BETALD). Human CHDH activity is inferred from rat Chdh (Huang & Lin 2003). While CHDH is associated with FAD, and plausible electron transfer schemes from FADH2 have been hypothesized for this reaction (e.g., Packer et al. 1960), direct experimental evidence for FAD as the hydrogen acceptor in this reaction is lacking and so it is annotated heer with a generic acceptor and donor.

Literature References
PubMed ID Title Journal Year
14429690 Studies on choline dehydrogenase. II. Components of the choline oxidase system and the site of action of amytal

Packer, L, Estabrook, RW, Singer, TP, Kimura, T

J Biol Chem 1960
12951056 Functional expression and processing of rat choline dehydrogenase precursor

Huang, S, Lin, Q

Biochem. Biophys. Res. Commun. 2003
Participants
Participates
Catalyst Activity

choline dehydrogenase activity of CHDH [mitochondrial inner membrane]

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