Reactome | CHDH oxidises Cho to BETALD

CHDH oxidises Cho to BETALD

Stable Identifier

R-HSA-6797961

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial choline dehydrogenase (CHDH), located on the inner mitochondrial membrane, catalyses the oxidation of choline (Cho) to betaine aldehyde (BETALD). Human CHDH activity is inferred from rat Chdh (Huang & Lin 2003). While CHDH is associated with FAD, and plausible electron transfer schemes from FADH2 have been hypothesized for this reaction (e.g., Packer et al. 1960), direct experimental evidence for FAD as the hydrogen acceptor in this reaction is lacking and so it is annotated heer with a generic acceptor and donor.

Literature References

PubMed ID	Title	Journal	Year
14429690	Studies on choline dehydrogenase. II. Components of the choline oxidase system and the site of action of amytal Packer, L, Estabrook, RW, Singer, TP, Kimura, T	J Biol Chem	1960
12951056	Functional expression and processing of rat choline dehydrogenase precursor Huang, S, Lin, Q	Biochem. Biophys. Res. Commun.	2003