Mitochondrial choline dehydrogenase (CHDH), located on the inner mitochondrial membrane, catalyses the oxidation of choline (Cho) to betaine aldehyde (BETALD). Human CHDH activity is inferred from rat Chdh (Huang & Lin 2003). While CHDH is associated with FAD, and plausible electron transfer schemes from FADH2 have been hypothesized for this reaction (e.g., Packer et al. 1960), direct experimental evidence for FAD as the hydrogen acceptor in this reaction is lacking and so it is annotated heer with a generic acceptor and donor.
Packer, L, Estabrook, RW, Singer, TP, Kimura, T
Huang, S, Lin, Q
choline dehydrogenase activity of CHDH [mitochondrial inner membrane]
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