SLC44A1 transports Cho from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-6797956
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix, mitochondrial outer membrane
ReviewStatus
5/5
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SLC44A1 transports Cho from cytosol to mitochondrial matrix
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The choline transporter-like protein 1 (SLC44A1) as an important mediator of choline transport across both the plasma membrane and the mitochondrial membrane. It is an essential step in the oxidation of Cho to betaine, which occurs in the mitochondrial matrix (Michel & Bakovic 2009).

Literature References
PubMed ID Title Journal Year
19357133 The solute carrier 44A1 is a mitochondrial protein and mediates choline transport

Michel, V, Bakovic, M

FASEB J. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

choline transmembrane transporter activity of SLC44A1 [mitochondrial outer membrane]

Physical Entity
SLC44A1 [mitochondrial outer membrane] (Homo sapiens)
Activity
choline transmembrane transporter activity (GO:0015220)
Orthologous Events
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Bos taurus)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Canis familiaris)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Danio rerio)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Dictyostelium discoideum)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Drosophila melanogaster)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Gallus gallus)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Mus musculus)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Sus scrofa)
SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-09-16)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-16)
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