ALDH7A1 oxidises BETALD to BET

Stable Identifier
R-HSA-6797955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) is a multifunctional enzyme present in mitochondria, nucleus and the cytosol and plays an important role in protecting against hyperosmotic stress and metabolising toxic aldehydes. It is able to oxidise the osmolyte precursor betaine aldehyde (BETALD) to betaine (BET) (as well as the intermediate lysine degradation product, alpha-aminoadipic semialdehyde, not shown here) (Brocker et al. 2010). The mitochondrial isoform of ALDH7A1 is shown here.

Literature References
PubMed ID Title Journal Year
20207735 Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress

Lassen, N, Pappa, A, Chavakis, T, Brocker, C, Orlova, VV, Oppermann, U, Cantore, M, Vasiliou, V, Kavanagh, KL, Estey, T

J. Biol. Chem. 2010
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Participates
Catalyst Activity

betaine-aldehyde dehydrogenase activity of ALDH7A1 [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
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