LRPP4(LRPP1-3,5) hydrolyse LPA

Stable Identifier
Reaction [transition]
Homo sapiens
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Human plasticity-related genes (PRGs, lipid phosphate phosphatase-related proteins LPPRs) comprise 5 members expressed in the CNS. They are membrane-spanning enzymes thought to mediate the extracellular concentration and signal transduction of lipid phosphate esters such as lysophosphatidic acid (LPA) and spingosine-1 phosphate (S1P) by hydrolysing their phosphate groups. LPPR4 has been shown to act as an ecto-enzyme in axon growth and regenerative sprouting by mediating LPA levels (Brauer et al. 2003). The activity of the other LPPR members has yet to be defined (Strauss & Brauer 2013).

Literature References
PubMed ID Title Journal Year
12730698 A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

Nitsch, R, Savaskan, NE, Kühn, H, Bräuer, AU, Ninnemann, O, Prehn, S

Nat. Neurosci. 2003
23388400 Current views on regulation and function of plasticity-related genes (PRGs/LPPRs) in the brain

Bräuer, AU, Strauss, U

Biochim. Biophys. Acta 2013
Catalyst Activity

phosphatidate phosphatase activity of LPPR4(LPPR1-3,5) [plasma membrane]

Orthologous Events
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