Reactome | CCNK:CDK12 binds RNA Pol II at DNA repair genes

CCNK:CDK12 binds RNA Pol II at DNA repair genes

Stable Identifier

R-HSA-6797616

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CCNK:CDK12 binds RNA Pol II at DNA repair genes

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex of CDK12 and CCNK (cyclin K) associates with the RNA polymerase II (RNA Pol II) elongation complex at DNA repair genes encoding long primary transcripts, such as BRCA1, ATR, FANCI, FANCD2, ATM, MDC1, CHEK1, RAD51D and APEX1 (Blazek et al. 2011, Bartkowiak and Greenleaf 2015, Ekumi et al. 2015, Liang et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25429106	Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex Bartkowiak, B, Greenleaf, AL	J. Biol. Chem.	2015
25712099	Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex Ekumi, KM, Paculova, H, Barboric, M, Bryja, V, Geyer, M, Rybarikova, J, Blazek, D, Pospichalova, V, Lenasi, T, Bösken, CA	Nucleic Acids Res.	2015
25561469	Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing Liang, K, Smith, E, Florens, LA, Shilatifard, A, Gilmore, JM, Gao, X, Washburn, MP	Mol. Cell. Biol.	2015
22012619	The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes Cimermancic, P, Johansen, E, Ule, J, Peterlin, BM, Hulinkova, P, Luo, Z, Blazek, D, Kohoutek, J, Bartholomeeusen, K	Genes Dev.	2011