CCNK:CDK12 binds RNA Pol II at DNA repair genes

Stable Identifier
R-HSA-6797616
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The complex of CDK12 and CCNK (cyclin K) associates with the RNA polymerase II (RNA Pol II) elongation complex at DNA repair genes encoding long primary transcripts, such as BRCA1, ATR, FANCI, FANCD2, ATM, MDC1, CHEK1, RAD51D and APEX1 (Blazek et al. 2011, Bartkowiak and Greenleaf 2015, Ekumi et al. 2015, Liang et al. 2015).

Literature References
PubMed ID Title Journal Year
25712099 Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Ekumi, KM, Paculova, H, Lenasi, T, Pospichalova, V, Bösken, CA, Rybarikova, J, Bryja, V, Geyer, M, Blazek, D, Barboric, M

Nucleic Acids Res. 2015
25429106 Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex

Bartkowiak, B, Greenleaf, AL

J. Biol. Chem. 2015
25561469 Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing

Liang, K, Gao, X, Gilmore, JM, Florens, LA, Washburn, MP, Smith, E, Shilatifard, A

Mol. Cell. Biol. 2015
22012619 The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

Blazek, D, Kohoutek, J, Bartholomeeusen, K, Johansen, E, Hulinkova, P, Luo, Z, Cimermancic, P, Ule, J, Peterlin, BM

Genes Dev. 2011
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