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Expression of HMOX1
Stable Identifier
R-HSA-6797268
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of HMOX1 (Homo sapiens)
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In human peripheral blood monocytes Interleukin-4 (IL4) and IL13 significantly upregulate the levels of proteins involved in inflammatory resolution, including the ER membrane protein 15-lipoxygenase (ALOX15) (Chaitidis et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15869882
Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13
Chaitidis, P
,
Bermudez-Fajardo, A
,
Kuban, RJ
,
O'Donnell, V
,
Kühn, H
,
Ungethuem, U
Cytokine
2005
Participants
Input
HMOX1 gene [nucleoplasm]
(Homo sapiens)
Output
HMOX1 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
This event is regulated
Positively by
Regulator
IL4, IL13 [extracellular region]
(Homo sapiens)
Authored
Jupe, S (2015-07-01)
Reviewed
Leibovich, SJ (2016-09-02)
Created
Jupe, S (2015-09-07)
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