Reactome | CCNK [nucleoplasm]

CCNK [nucleoplasm]

Stable Identifier

R-HSA-6796619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin-K, CPR4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
        
        P-TEFb complex [nucleoplasm] (Homo sapiens)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)
        
        CCNK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75909 CCNK

Gene Names

CCNK, CPR4

Chain

chain:1-580

Reference Genes

BioGPS Gene:8812 CCNK

COSMIC (genes):CCNK CCNK

CTD Gene:8812 CCNK

dbSNP Gene:8812 CCNK

ENSEMBL:ENSG00000090061 CCNK

HGNC:1596 CCNK

KEGG:hsa:8812 CCNK

Monarch:8812 CCNK

NCBI Gene:8812 CCNK

OMIM:603544 CCNK

UCSC:O75909 CCNK

Reference Transcript

Participates

as a component of

as an input of

as an output of

TP53 stimulates CCNK expression (Homo sapiens)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)

Inferred To

CCNK [nucleoplasm] (Bos taurus)

CCNK [nucleoplasm] (Canis familiaris)

CCNK [nucleoplasm] (Gallus gallus)

CCNK [nucleoplasm] (Sus scrofa)

ccnk [nucleoplasm] (Danio rerio)

ccnk [nucleoplasm] (Xenopus tropicalis)

pch1 [nucleoplasm] (Schizosaccharomyces pombe)

ccnk-1 [nucleoplasm] (Caenorhabditis elegans)

Ccnk [nucleoplasm] (Mus musculus)

Ccnk [nucleoplasm] (Rattus norvegicus)

BUR2 [nucleoplasm] (Saccharomyces cerevisiae)

cycK [nucleoplasm] (Dictyostelium discoideum)

CycK [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_005268211.1, NP_001092872.1, XP_011535577.1

OpenTargets

ENSG00000090061

ENSEMBL

ENST00000389879, ENSG00000090061, ENSP00000374529

HPA

ENSG00000090061-CCNK

GeneCards

CCNK

PRO

O75909

Pharos - Targets

O75909

GlyGen

O75909

PDB

8BUM, 8BUK, 8BUL, 8BUN, 8BUS, 7NXK, 8BUT, 8BUO, 8BUQ, 8BUP, 7NXJ, 8BUR, 8BU5, 8BU3, 8BU6, 8BU4, 6TD3, 9FMR, 8P81, 8BUC, 8BUE, 8BU1, 8BUD, 8BUF, 8BU2, 5ACB, 6B3E, 8BU7, 8BUA, 8BU9, 4UN0, 8BUB, 8BUG, 8BUI, 6CKX, 8BUJ, 8BUH, 4NST, 4CXA, 2I53, 5EFQ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14004 CDK13	3	CDK13 [nucleoplasm] (R-HSA-6797014) CDK13 [extracellular region] (R-HSA-6806442) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374)	0.826	10
UniProt:Q9NYV4 CDK12	1	CDK12 [nucleoplasm] (R-HSA-6797012)	0.688	5
UniProt:Q93062 RBPMS			0.666	4
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P54253 ATX1			0.508	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.462	2

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