Reactome | Homer1,2,3 binds mGluR1a,5

Homer1,2,3 binds mGluR1a,5

Stable Identifier

R-HSA-6794355

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Homer proteins are closely related neuronal scaffolding molecules that selectively binds the C-terminus of group 1 metabotropic or heterotrimeric GTP-binding protein-linked glutamate receptors (mGluR1a and mGluR5) and are enriched at excitatory synapses (Brakeman et al. 1997, Xiao et al. 1998). Homer proteins contain an amino-terminal EVH1 domain followed by a rod-shaped coiled-coil domain. The EVH1 domain of Homer can bind the proline rich motifs in mGluRs and the inositol 1,4,5-trisphosphate (IP3) receptors, thereby linking these receptors in a signalling complex (Tu et al. 1998, 1999).

Literature References

PubMed ID	Title	Journal	Year
9808458	Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins Breder, CD, Petralia, RS, Tu, JC, Doan, A, Yuan, JP, Xiao, B, Ruggiero, A, Wenthold, RJ, Worley, PF, Lanahan, AA	Neuron	1998
9069287	Homer: a protein that selectively binds metabotropic glutamate receptors Barnes, CA, Brakeman, PR, O'Brien, R, Huganir, RL, Worley, PF, Roche, K, Lanahan, AA	Nature	1997