Homer1,2,3 binds mGluR1a,5

Stable Identifier
R-HSA-6794355
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Homer proteins are closely related neuronal scaffolding molecules that selectively binds the C-terminus of group 1 metabotropic or heterotrimeric GTP-binding protein-linked glutamate receptors (mGluR1a and mGluR5) and are enriched at excitatory synapses (Brakeman et al. 1997, Xiao et al. 1998). Homer proteins contain an amino-terminal EVH1 domain followed by a rod-shaped coiled-coil domain. The EVH1 domain of Homer can bind the proline rich motifs in mGluRs and the inositol 1,4,5-trisphosphate (IP3) receptors, thereby linking these receptors in a signalling complex (Tu et al. 1998, 1999).

Literature References
PubMed ID Title Journal Year
9808458 Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins

Breder, CD, Petralia, RS, Tu, JC, Doan, A, Yuan, JP, Xiao, B, Ruggiero, A, Wenthold, RJ, Worley, PF, Lanahan, AA

Neuron 1998
9069287 Homer: a protein that selectively binds metabotropic glutamate receptors

Barnes, CA, Brakeman, PR, O'Brien, R, Huganir, RL, Worley, PF, Roche, K, Lanahan, AA

Nature 1997
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!