Homer proteins are closely related neuronal scaffolding molecules that selectively binds the C-terminus of group 1 metabotropic or heterotrimeric GTP-binding protein-linked glutamate receptors (mGluR1a and mGluR5) and are enriched at excitatory synapses (Brakeman et al. 1997, Xiao et al. 1998). Homer proteins contain an amino-terminal EVH1 domain followed by a rod-shaped coiled-coil domain. The EVH1 domain of Homer can bind the proline rich motifs in mGluRs and the inositol 1,4,5-trisphosphate (IP3) receptors, thereby linking these receptors in a signalling complex (Tu et al. 1998, 1999).
Breder, CD, Petralia, RS, Tu, JC, Doan, A, Yuan, JP, Xiao, B, Ruggiero, A, Wenthold, RJ, Worley, PF, Lanahan, AA
Barnes, CA, Brakeman, PR, O'Brien, R, Huganir, RL, Worley, PF, Roche, K, Lanahan, AA
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