Homer1,2,3 binds mGluR1a,5

Stable Identifier
R-HSA-6794355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Homer1,2,3 binds mGluR1a,5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Homer proteins are closely related neuronal scaffolding molecules that selectively binds the C-terminus of group 1 metabotropic or heterotrimeric GTP-binding protein-linked glutamate receptors (mGluR1a and mGluR5) and are enriched at excitatory synapses (Brakeman et al. 1997, Xiao et al. 1998). Homer proteins contain an amino-terminal EVH1 domain followed by a rod-shaped coiled-coil domain. The EVH1 domain of Homer can bind the proline rich motifs in mGluRs and the inositol 1,4,5-trisphosphate (IP3) receptors, thereby linking these receptors in a signalling complex (Tu et al. 1998, 1999).

Literature References
PubMed ID Title Journal Year
9069287 Homer: a protein that selectively binds metabotropic glutamate receptors

Brakeman, PR, Lanahan, AA, O'Brien, R, Roche, K, Barnes, CA, Huganir, RL, Worley, PF

Nature 1997
9808458 Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins

Xiao, B, Tu, JC, Petralia, RS, Yuan, JP, Doan, A, Breder, CD, Ruggiero, A, Lanahan, AA, Wenthold, RJ, Worley, PF

Neuron 1998
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Homer1,2,3 binds mGluR1a,5 (Bos taurus)
Homer1,2,3 binds mGluR1a,5 (Canis familiaris)
Homer1,2,3 binds mGluR1a,5 (Danio rerio)
Homer1,2,3 binds mGluR1a,5 (Gallus gallus)
Homer1,2,3 binds mGluR1a,5 (Mus musculus)
Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)
Homer1,2,3 binds mGluR1a,5 (Sus scrofa)
Homer1,2,3 binds mGluR1a,5 (Xenopus tropicalis)
Authored
Garapati, P V  (2015-09-04)
Reviewed
Washbourne, P  (2015-11-09)
Created
Garapati, P V  (2015-09-04)