Homer1,2,3 binds mGluR1a,5

Stable Identifier
R-HSA-6794355
Type
Reaction [binding]
Species
Homo sapiens
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Homer proteins are closely related neuronal scaffolding molecules that selectively binds the C-terminus of group 1 metabotropic or heterotrimeric GTP-binding protein-linked glutamate receptors (mGluR1a and mGluR5) and are enriched at excitatory synapses (Brakeman et al. 1997, Xiao et al. 1998). Homer proteins contain an amino-terminal EVH1 domain followed by a rod-shaped coiled-coil domain. The EVH1 domain of Homer can bind the proline rich motifs in mGluRs and the inositol 1,4,5-trisphosphate (IP3) receptors, thereby linking these receptors in a signalling complex (Tu et al. 1998, 1999).

Literature References
PubMed ID Title Journal Year
9069287 Homer: a protein that selectively binds metabotropic glutamate receptors

Brakeman, PR, Lanahan, AA, O'Brien, R, Roche, K, Barnes, CA, Huganir, RL, Worley, PF

Nature 1997
9808458 Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins

Xiao, B, Tu, JC, Petralia, RS, Yuan, JP, Doan, A, Breder, CD, Ruggiero, A, Lanahan, AA, Wenthold, RJ, Worley, PF

Neuron 1998
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