Homer1,2,3 dimerizes

Stable Identifier
R-HSA-6794347
Type
Reaction
Species
Homo sapiens
Compartment
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Homer dimerizes via the coiled-coil domains to form a rod with EVH1 domains on either end. It could interact with mGluRs on one end and with the other EVH1 domain can bind to Shank proteins linking the two receptors together (Hayashi et al. 2009).

Literature References
PubMed ID Title Journal Year
9808458 Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins

Breder, CD, Petralia, RS, Tu, JC, Doan, A, Yuan, JP, Xiao, B, Ruggiero, A, Wenthold, RJ, Worley, PF, Lanahan, AA

Neuron 1998
9069287 Homer: a protein that selectively binds metabotropic glutamate receptors

Barnes, CA, Brakeman, PR, O'Brien, R, Huganir, RL, Worley, PF, Roche, K, Lanahan, AA

Nature 1997
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