Reactome | Homer1,2,3 dimerizes

Homer1,2,3 dimerizes

Stable Identifier

R-HSA-6794347

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Homer dimerizes via the coiled-coil domains to form a rod with EVH1 domains on either end. It could interact with mGluRs on one end and with the other EVH1 domain can bind to Shank proteins linking the two receptors together (Hayashi et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
9808458	Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins Xiao, B, Tu, JC, Petralia, RS, Yuan, JP, Doan, A, Breder, CD, Ruggiero, A, Lanahan, AA, Wenthold, RJ, Worley, PF	Neuron	1998
9069287	Homer: a protein that selectively binds metabotropic glutamate receptors Brakeman, PR, Lanahan, AA, O'Brien, R, Roche, K, Barnes, CA, Huganir, RL, Worley, PF	Nature	1997