Neuroligins (NLGNs) bind to the third PDZ domain of postsynaptic density (PSD)-95 whereas NMDA receptor and K+ channels interact with the first and the second PDZ domains. The cytoplasmic domains of all three neuroligins interacts with the NH2-terminus of PSD-95 and its homologs PSD-93 and SAP102, which contains the three PDZ domains (Irie et al. 1997).
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