Reactome | DLGAP2 [plasma membrane]

DLGAP2 [plasma membrane]

Stable Identifier

R-HSA-6794266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Disks large-associated protein 2, DLGP2_HUMAN, GKAP2

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - ABP1 binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
    - GKAPs bind PSD-95 members (Homo sapiens)
      - GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
    - HOMER binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
    - SHANK proteins bind GKAPs (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P1A6 DLGAP2

Gene Names

DLGAP2, DAP2, C8orf68, ERICH1-AS1

Chain

chain:1-1054

Reference Genes

COSMIC (genes):DLGAP2 DLGAP2

ENSEMBL:ENSG00000198010 DLGAP2

HGNC:2906 DLGAP2

OMIM:605438 DLGAP2

UCSC:Q9P1A6 DLGAP2

Reference Transcript

RefSeq:NM_004745.4 DLGAP2

Other Identifiers

11763515_a_at

17065138

216916_s_at

2405933

3082645

3082648

3082671

3082762

3082768

3082769

3082772

3082782

3082783

3082788

3082789

3082791

3082792

3082799

3082800

3082801

3082802

31712_at

31713_s_at

3796622

8144253

9228

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005883

GO:0005886

GO:0007267

GO:0007270

GO:0008150

GO:0014069

GO:0016020

GO:0023052

GO:0030054

GO:0043226

GO:0045202

Hs.113287.1.S1_3p_a_at

TC08000007.hg

Participant Of

hasMember

GKAP1-4 [plasma membrane]

Inferred To

DLGAP2 [plasma membrane] (Bos taurus)

DLGAP2 [plasma membrane] (Caenorhabditis elegans)

DLGAP2 [plasma membrane] (Canis familiaris)

DLGAP2 [plasma membrane] (Gallus gallus)

DLGAP2 [plasma membrane] (Sus scrofa)

dlgap2 [plasma membrane] (Xenopus tropicalis)

Dlgap2 [plasma membrane] (Mus musculus)

Dlgap2 [plasma membrane] (Rattus norvegicus)

Homologues of DLGAP2 [plasma membrane] (Danio rerio)

dlgap2a [plasma membrane] (Danio rerio)

vlc [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_004736.2

OpenTargets

ENSG00000198010

GeneCards

Q9P1A6

HPA

ENSG00000198010-DLGAP2

Ensembl

ENST00000421627, ENSG00000198010, ENSP00000400258

PRO

Q9P1A6

Orphanet

26208