Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SHANK2 [cytosol]
Stable Identifier
R-HSA-6794265
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH3 and multiple ankyrin repeat domains protein 2, SHAN2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
ABP1 binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
HOMER binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
SHANK proteins bind GKAPs (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
SHARPIN binds SHANK proteins (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
SHARPIN:SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPX8 SHANK2
Gene Names
SHANK2, CORTBP1, KIAA1022, PROSAP1
Chain
chain:1-1849
Reference Genes
BioGPS Gene:22941 SHANK2
COSMIC (genes):SHANK2 SHANK2
CTD Gene:22941 SHANK2
dbSNP Gene:22941 SHANK2
ENSEMBL:ENSG00000162105.21 SHANK2
HGNC:14295 SHANK2
KEGG Gene (Homo sapiens):22941 SHANK2
Monarch:22941 SHANK2
NCBI Gene:22941 SHANK2
OMIM:603290 SHANK2
UCSC:Q9UPX8 SHANK2
Reference Transcript
RefSeq:NM_133266.4 SHANK2
RefSeq:XM_017017388.1 SHANK2
RefSeq:XM_005277932.3 SHANK2
RefSeq:XM_017017387.1 SHANK2
RefSeq:NM_012309.4 SHANK2
Other Identifiers
0000430110
0003440020
0003800010
11734020_a_at
11734021_at
11738310_a_at
11756009_a_at
16741442
213307_PM_at
213307_at
213308_PM_at
213308_at
22941
243681_PM_at
243681_at
3380370
3380371
3380372
3380373
3380374
3380375
3380378
3380379
3380380
3380381
3380382
3380383
3380384
3380385
3380386
3380387
3380391
3380392
3380393
3380407
3380408
3380469
3380470
3380471
3380497
3380525
3380533
3380539
3380543
3380544
3380545
3380558
3380579
3380580
3380585
3380586
3380590
3380591
3380598
3380610
3380613
3380614
37806_at
44325_at
7950042
A_19_P00808452
A_23_P334883
A_33_P3374010
GE53699
GO:0001750
GO:0001917
GO:0005198
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005883
GO:0005886
GO:0005929
GO:0007416
GO:0007420
GO:0007584
GO:0007612
GO:0008022
GO:0008284
GO:0008306
GO:0008344
GO:0009410
GO:0014069
GO:0016020
GO:0016324
GO:0017124
GO:0023052
GO:0030160
GO:0030426
GO:0030534
GO:0031526
GO:0032279
GO:0034330
GO:0035176
GO:0035255
GO:0035331
GO:0042995
GO:0043005
GO:0043025
GO:0043197
GO:0043226
GO:0045202
GO:0045211
GO:0048786
GO:0048856
GO:0050807
GO:0050877
GO:0060090
GO:0060170
GO:0060291
GO:0060292
GO:0071625
GO:0098686
GO:0098919
GO:0098978
GO:0099562
HMNXSV003030304
Hs.12696.0.S1_3p_at
Hs.12696.0.S2_3p_at
Hs.19569.0.A1_3p_at
ILMN_1745151
ILMN_1814790
ILMN_3237114
PH_hs_0001206
PH_hs_0018296
PH_hs_0036074
TC11002030.hg
Participates
as a member of
SHANK1,2,3 [cytosol] (Homo sapiens)
Inferred To
Prosap [cytosol]
(Drosophila melanogaster)
shank2 [cytosol]
(Danio rerio)
shank2 [cytosol]
(Xenopus tropicalis)
shn-1 [cytosol]
(Caenorhabditis elegans)
Shank2 [cytosol]
(Mus musculus)
Shank2 [cytosol]
(Rattus norvegicus)
SHANK2 [cytosol]
(Bos taurus)
SHANK2 [cytosol]
(Canis familiaris)
SHANK2 [cytosol]
(Gallus gallus)
SHANK2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016872876.1
,
NP_036441.2
,
XP_016872877.1
,
XP_005277989.1
,
NP_573573.2
OpenTargets
ENSG00000162105
HPA
ENSG00000162105-SHANK2
GeneCards
Q9UPX8
Ensembl
ENSP00000469689
,
ENSG00000162105
,
ENST00000656230
,
ENST00000601538
,
ENSP00000499561
PRO
Q9UPX8
Pharos - Targets
Q9UPX8
Orphanet
22648
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [plasma membrane]
(R-HSA-167682)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.602
4
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text