Reactome | PDLIM5 [cytosol]

PDLIM5 [cytosol]

Stable Identifier

R-HSA-6794246

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PDZ and LIM domain protein 5, PDLI5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y6C2 EMILIN1

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External Reference Information

External Reference

UniProt:Q96HC4 PDLIM5

Gene Names

PDLIM5, ENH, L9

Chain

initiator methionine:, chain:2-596

Reference Genes

BioGPS Gene:10611 Q96HC43

COSMIC (genes):PDLIM5 PDLIM5

CTD Gene:10611 PDLIM5

dbSNP Gene:10611 PDLIM5

ENSEMBL:ENSG00000163110 PDLIM5

HGNC:17468 Q96HC43

KEGG:hsa:10611 Q96HC43

Monarch:10611 Q96HC43

NCBI Gene:10611 Q96HC43

OMIM:605904 Q96HC43

UCSC:Q96HC4 Q96HC43

Reference Transcript

Participates

as a component of

NMDA receptor complex:DLG2,DLG3,DLG4:SPAR:PDLIM5 [plasma membrane] (Homo sapiens)

as an input of

NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)

Cross References

RefSeq

NP_006448.5, NP_001011513.4, NP_001011515.1, NP_006448.4, NP_001243355.2, NP_001243356.2, NP_001011516.1, NP_001243358.1

ENSEMBL

ENST00000317968, ENST00000359265, ENST00000318007, ENST00000380180, ENSP00000424360, ENSP00000480359, ENSP00000321746, ENSP00000424297, ENST00000542407, ENSG00000163110, ENSP00000322021, ENST00000615540, ENST00000503974, ENSP00000369527, ENST00000508216, ENSP00000426804, ENSP00000442187, ENSP00000352210, ENST00000514743

OpenTargets

ENSG00000163110

GeneCards

PDLIM5

HPA

ENSG00000163110-PDLIM5

PRO

Q96HC4

Pharos - Targets

Q96HC4

GlyGen

Q96HC4

PDB

2DAR, 2UZC

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38432 COIL			0.666	4
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.633	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q15942 ZYX			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:O43583 DENR			0.527	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.527	2
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.527	2
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.527	6
UniProt:Q8NCF5 NF2IP			0.527	2
UniProt:P57060 RWD2B			0.527	2
UniProt:Q8TCB7 METL6			0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

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