Expression of STAT6-upregulated extracellular proteins

Stable Identifier
Reaction [omitted]
Homo sapiens
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Phosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyperresponsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the extracellular proteins C-C motif chemokine 11 (CCL11, Eotaxin) (Matsukura et al. 1999), Ig epsilon chain C region (IGHE) (Stütz & Woisetschlager 1999), Ig gamma-1 chain C region (IGHG1) (Warren et al. 1999) and Ig gamma-4 chain C region (IGHG4) (Hebenstreit et al. 2006).
Literature References
PubMed ID Title Journal Year
10510379 Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription

Woisetschläger, M, Stütz, AM

J. Immunol. 1999
10369418 Regulation of the germline immunoglobulin Cgamma1 promoter by CD40 ligand and IL-4: dual role for tandem NF-kappaB binding sites

Berton, MT, Roberts, KL, Warren, WD, Linehan, LA

Mol. Immunol. 1999
16540365 Signaling mechanisms, interaction partners, and target genes of STAT6

Duschl, A, Hebenstreit, D, Horejs-Hoeck, J, Wirnsberger, G

Cytokine Growth Factor Rev. 2006
10586089 Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells

Casolaro, V, Georas, SN, Miura, K, Stellato, C, Matsukura, S, Schleimer, RP, Plitt, JR, Bickel, C

J. Immunol. 1999
This event is regulated
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