Expression of STAT6-upregulated plasma membrane proteins

Stable Identifier
R-HSA-6793958
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of STAT6-upregulated plasma membrane proteins
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyperresponsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the cell surface proteins Interleukin-4 receptor alpha (IL4R) (Matsukura et al. 1999) and Low affinity immunoglobulin epsilon Fc receptor (FCER2) (Takeda et al. 1994, Park et al. 1998). IL4 links the immune system to the opioid system by inducing transcription of the mu- and delta-opioid receptors (MOR, DOR) (Borner et al. 2004, Kraus et al. 2001) and pro-opiomelanocortin (POMC) (Busch-Dienstfertig et al. 2012). Opioid receptor gene expression in T cells is STAT6-dependent while POMC gene expression in lymphocytes is mediated by STAT3 (Busch-Dienstfertig & González-Rodríguez 2013).
Literature References
PubMed ID Title Journal Year
8602263 Essential role of Stat6 in IL-4 signalling

Yoshida, N, Shi, W, Kishimoto, T, Nakanishi, K, Matsumoto, M, Akira, S, Kashiwamura, S, Tanaka, T, Minami, M, Takeda, K

Nature 1996
9736340 Interferon-gamma-induced factor binding to the interleukin-4-responsive element of CD23b promoter in human tonsillar mononuclear cells: role in transient up-regulation of the interleukin-4-induced CD23b mRNA

So, EY, Lee, CE, Park, HJ

Mol. Immunol. 1998
14634100 IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site

Frischauf, AM, Schmiedlechner, A, Duschl, A, Aberger, F, Luft, P, Hebenstreit, D, Horejs-Hoeck, J, Regl, G

J. Immunol. 2003
10586089 Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells

Casolaro, V, Georas, SN, Miura, K, Stellato, C, Matsukura, S, Schleimer, RP, Plitt, JR, Bickel, C

J. Immunol. 1999
15584925 STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors

Höllt, V, Kraus, J, Wöltje, M, Börner, C

J. Neurochem. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-Y641-STAT6 dimer [nucleoplasm] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-09-04)
Cite Us!